Hmmm...

I have several machines, all of which use Online Armor Pro for firewalls.
AV is either ESETNod 32 v.4 or Sunbelt Vipre 4, depending on the machine.
Antispy/antmalware: MBAM Pro and A-square Pro on all.
Winpatrol Plus on all.

I routinely scan the machines, usually weekly, and do incremental back-ups with Genie-Soft Backup Manager daily.
Weekly incremental images with Acronis TI 2010; monthly full images. The backups and images are done after hours.